Keke Ding

Keywords MASH MASLD gut microbiota acetaldehyde sugar MMP7 probiotics acetaldehyde-alcohol dehydrogenase hepatic stellate cells Introduction Metabolic dysfunction-associated steatohepatitis (MASH), the progressive inflammatory stage of metabolic dysfunction-associated steatotic liver disease (MASLD), is a leading cause of liver-related morbidity and mortality worldwide. It is closely linked to rapid hepatic deterioration and often necessitates liver transplantation.

Abstract Amino acids are fundamental to human physiology, yet their impact on growth, development, and aging remains elusive. Here, we introduce AmiAge, a biological age predictor constructed using a Random Forest model trained on the concentrations of 18 amino acids across individuals aged 1 to 89 years.

Keywords microbiota metabolism depression correlations mediation analysis machine learning Introduction Depression presents a substantial burden on both individuals and society, with an increasing prevalence.1,2 Current diagnostic methods rely heavily on clinical interviews and scale scores like the Hamilton Depression Scale (HAMD)-17 test3 and the Patient Health Questionnaire-9 depression module.4 However, patients’ reluctance to disclose their true state and subjective evaluations by...