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Kelley DePierri on Muck Rack

Kelley DePierri

As seen in: The Journal of Immunology
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Articles by Kelley DePierri

Loss of humoral immunity in a mouse model of ovarian cancer

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By James Edward Riggs, Kelley DePierri, Naomi Goldman, Gretel Torres, Wilenny Rodriguez
| The Journal of Immunology Verified
Although a low incidence cancer, ovarian carcinoma (OvCa) has a high mortality rate due to late detection. To study the humoral immune response to OvCa we transplant ID8 cells (mouse epithelial carcinoma) into the murine peritoneal cavity (PerC). We found that as the OvCa developed PerC B cells, particularly B-1 B cells, were depleted. To assess the systemic impact of this depletion we assessed humoral immunity. We found a reduction in “natural” IgM and IgG production and increased IgA and IgG .
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B cell subset biology in a tumor microenvironment model

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By James Edward Riggs, Naomi Goldman, Kornelija Valiuskyte, Kelley DePierri, John Somerville
| The Journal of Immunology Verified
The high myeloid to lymphoid ratio of cultured peritoneal cavity (PerC) leukocytes can serve as an in vitro model to study the tumor microenvironment (TME). C57BL/6J PerC T cell responses to TCR ligation (anti-CD3) and mitogen (ConA) are suppressed in these cultures. Likewise, the PerC B cell response to BCR (F[ab’ ] anti-IgM) and TLR4 (TLR4L/LPS) ligation are suppressed. T cell suppression can be liberated by neutralizing IFNγ or by blocking iNOS with 1-methyl arginine.
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