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Kornelija Valiuskyte on Muck Rack

Kornelija Valiuskyte

As seen in: The Journal of Immunology
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Articles

B cell subset biology in a tumor microenvironment model

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By James Edward Riggs, Naomi Goldman, Kornelija Valiuskyte, Kelley DePierri, John Somerville
| The Journal of Immunology Verified
The high myeloid to lymphoid ratio of cultured peritoneal cavity (PerC) leukocytes can serve as an in vitro model to study the tumor microenvironment (TME). C57BL/6J PerC T cell responses to TCR ligation (anti-CD3) and mitogen (ConA) are suppressed in these cultures. Likewise, the PerC B cell response to BCR (F[ab’ ] anti-IgM) and TLR4 (TLR4L/LPS) ligation are suppressed. T cell suppression can be liberated by neutralizing IFNγ or by blocking iNOS with 1-methyl arginine.
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