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Kelsey Maher

As seen in: BioRxiv, Cell Reports Medicine

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Articles

3D-super-enhancers are condensate-associated cis-regulatory communities

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By Jie Lv, Kelsey Maher, Li Dong, Virginia Valentine
| BioRxiv
Abstract Transcription proteins are concentrated at nuclear transcriptional condensates. These condensates contain cis-regulatory elements (CREs), including enhancers and promoters, that are thought to regulate genes in the same condensate.
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STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma

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By Nicole Prutsch, Adam D. Durbin Verified, Kelsey Maher, Jamie Matthews
| Cell Reports Medicine Verified
Highlights • BATF3, IRF4, and IKZF1 form a transcriptional core regulatory circuit in ALCL • Active STAT3 binds cooperatively with BATF3, IRF4, and IKZF1 at gene enhancers • The transcriptome driven by this network includes MYC and other prosurvival genes • STAT3, BATF3, IRF4, and IKZF1 are targetable selective gene dependencies in ALCL Summary Anaplastic large cell lymphoma (ALCL) is an aggressive, CD30+ T cell lymphoma of children and adults.
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Topology-informed regulatory element collections coordinate cell identity gene expression programs

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By Jie Lv, Kelsey Maher, Alaguraj Veluchamy, Yuna Kim
| BioRxiv
Abstract Cis-regulatory elements (CREs) contact target genes to regulate their transcription, but CRE interactions are complex and predicting their function is challenging. Contemporary approaches to predict CRE targets generally assume one-to-one associations and linear genomic proximity.
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