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Keng Hee Peh

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Articles

Macrophage Repolarization as a Therapeutic Strategy for Osteosarcoma

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By Jill M. Kolesar, Namrata Anand, Keng Hee Peh, Keng Hee
| MDPI
Abstract : Macrophages are versatile immune cells and can adapt to both external stimuli and their surrounding environment. Macrophages are categorized into two major categories; M1 macrophages release pro-inflammatory cytokines and produce protective responses that lead to antimicrobial or antitumor activity. M2 or tumor-associated macrophages (TAM) release anti-inflammatory cytokines that support tumor growth, invasion capacity, and metastatic potential.
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