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Kenneth Anthony Roquid

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Articles

Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis

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By Robert A Kozol, Peishi Rao, Yvonne T. Kschonsak, Haruya Kawase, Shangmin Liu, Sabrina Kurz, Verena Bengelsdorff, Remy Bonnavion, Young-June Jin, Kenneth Anthony Roquid, Haaglim Cho, Guozheng Liang, Marija Banićević, Niharika Shiva, Paula Sofia Yunes-Leites, Stefan Günther, Lukas Tombor, Stefanie Dimmeler, Mario Looso, Kenny Mattonet, Nina Wettschureck, Ulrike Müller, Stefan Offermanns
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Amyloid precursor protein (APP) gives rise to amyloid-β, a pathological factor in Alzheimer’s disease. However, the physiological role of APP and its homolog amyloid precursor–like protein 2 (APLP2), which are also widely expressed outside the nervous system, is largely unknown.
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Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes

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By Shixin Ma, Léa Meneu, Hongbo Liu, Sheng Wang, Haaglim Cho, Haruya Kawase, Diana Campos, Min Chen, Lee Weinstein, Alfredo Martinez, Alfredo Martínez Verified, Mario Looso, Miloslav Sanda, Stefan Offermanns, Kenneth Anthony Roquid
| Science Magazine Verified
Editor’s summary Insulin resistance, often induced by obesity, is the underlying abnormality for type 2 diabetes. Most studies looking at mechanisms for obesity and insulin resistance have examined cells known to play key roles in metabolism, such as those in the liver, skeletal muscle, and adipose tissue. Cho et al. shifted their focus to the vasculature, more specifically, endothelial insulin signaling.
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