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Kenneth Dunner Jr. on Muck Rack

Kenneth Dunner Jr.

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Inflammatory neuropathy in mouse and primate models of colorectal cancer

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By Caitlyn Gaffney, Angela M Casaril, Iqbal Mahmud, Bo Wei, Nathan T. Fiore, Jialu Liu, Karen Valadez, Elizabeth Kolb, Fisher R. Cherry, Philip L. Lorenzi, Steven Reiken, Peter Grace, Rajasekaran Mahalingam, Carolyn L. Hodo, Andrew Shepherd, Kenneth Dunner Jr.
| Nature Verified
Abstract Colorectal cancer survivors are at increased risk of developing neurological issues, particularly peripheral neuropathy and chronic pain. Although pre-existing neuropathy is a risk factor for chronic pain, tumor-induced neuropathy has not been firmly established in pre-clinical models. Consistent with clinical observations, we show that mice with colorectal cancer develop peripheral neuropathy, which was associated with subtle locomotor deficits, without overt hypersensitivity.
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