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Articles by Kent Doi
Critical care access and outcomes in residents of inpatient-care catchment areas with and without ICUs: a nationwide cohort study in Japan
Keywords Intensive care units Health services accessibility Healthcare disparities Secondary medical areas Japan Abbreviations CRRT (Continuous Renal Replacement Therapy) DPC (Diagnosis Procedure Combination) ICU (Intensive Care Unit) IMV (Invasive Mechanical Ventilation) MCS (Mechanical Circulatory Support) SMA (Secondary Medical Area) TMA (Tertiary Medical Area) Evidence before this study We searched PubMed for studies published from database inception to April 9, 2026, without language...
Mortality of severe pneumonia treated with methylprednisolone versus hydrocortisone: a propensity-matched analysis - Journal of Intensive Care
In this retrospective cohort study, we utilized the Japanese Diagnosis Procedure Combination (DPC) database, a nationwide administrative inpatient database previously reported [16, 17], to compare in-hospital mortality due to severe pneumonia between patients treated with mPSL and those treated with hydrocortisone. The database encompasses data from over 1,000 hospitals, representing approximately 50% of all discharges from acute care hospitals in Japan.
Predictive efficacy of plasma arginase 1 as a novel biomarker for mechanical ventilated patients with sepsis induced acute respiratory distress syndrome: a prospective cohort study
Keyword arginase 1 sepsis acute respiratory distress syndrome neutrophil biomarker Get full text access Log in, subscribe or purchase for full access. References 1. Bos, L.D.J. ∙ Ware, L.B. Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes The Lancet. 2022; 400:1145-1156 2. Wilson, J.G. ∙ Calfee, C.S. ARDS Subphenotypes: Understanding a Heterogeneous Syndrome Critical Care. 2020; 24:102 3. Lippi, G. ∙ Sanchis-Gomar, F. ∙ Henry, B.
In Pursuit of Transformational Clinical Solutions
Open AccessEditorial by Kent Doi SciProfiles Scilit Preprints.org Google Scholar Department of Emergency and Critical Care Medicine, University of Tokyo, Tokyo 113-8655, Japan J. Clin. Med. 2024, 13(11), 3021; https://doi.org/10.3390/jcm13113021 (registering DOI) Submission received: 17 May 2024 / Accepted: 17 May 2024 / Published: 21 May 2024 It gives me great pleasure to introduce myself as the new Co-Editor-in-Chief of the Journal of Clinical Medicine (JCM).
Dynamic modulations of urinary sphingolipid and glycerophospholipid levels in COVID-19 and correlations with COVID-19-associated kidney injuries - Journal of Biomedical Science
Samples We collected the residual urinary samples after routine clinical testing from 91 subjects who had been diagnosed as having COVID-19 using an RT-PCR assay between September 2020 and April 2021. The sampling times were classified into the following eight periods: day 1–3, day 4–6, day 7–9, day 10–12, day 13–15, day 16–18, day 19–24, and day 25–40 after symptom onset.
Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series
Development of specific therapy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently required. Several drugs such as antimalarial and anti-Ebola virus drugs are under investigation for coronavirus disease 2019 (Covid-19). Transmembrane protease serine 2 (TMPRSS2) plays a crucial role for SARS-CoV-2 entry into the cytoplasm [1]. Inhibition of TMPRSS2 protease activity is assumed to prohibit viral entry of SARS-CoV-2.
Right subdiaphragmatic renal ectopia mimicking lung tumour
Right subdiaphragmatic renal ectopia mimicking lung tumour Ichiro Hirayama1, Ryota Inokuchi1, Masataka Fukue2, Kent Doi1 1 Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan 2 Department of Surgery, Koga General Hospital, Koga, Ibaraki, Japan Correspondence to Dr Ryota Inokuchi, Emergency and Critical Care Medicine, The University of Tokyo Hospital, Bunkyo-ku 113-8655, Japan; intensivecareunits{at}gmail.com Statistics from...
Right subdiaphragmatic renal ectopia mimicking lung tumour
Right subdiaphragmatic renal ectopia mimicking lung tumour Ichiro Hirayama1, Ryota Inokuchi1, Masataka Fukue2, Kent Doi1 1Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan 2Department of Surgery, Koga General Hospital, Koga, Ibaraki, Japan Correspondence to Dr Ryota Inokuchi, Emergency and Critical Care Medicine, The University of Tokyo Hospital, Bunkyo-ku 113-8655, Japan; intensivecareunits{at}gmail.com Statistics from Altmetric.com...
The Japanese Clinical Practice Guideline for acute kidney injury 2016
Recommendation: The use of biomarkers for the early diagnosis of AKI or to predict the survival outcomes cannot be recommended in children. Many studies have indicated that biomarkers such as NGAL, cystatin C, L-FABP, IL-18, and KIM-1 may be useful for the early diagnosis of AKI and to predict the survival outcomes in children. However, interventions based on these indicators have not been reported to improve the renal or survival outcomes of AKI; therefore, their utility is limited.
A critically ill patient after a colchicine overdose below the lethal dose: a case report
An 18-year-old woman who was prescribed colchicine used the drug at a dose of 15 mg (0.2 mg/kg). Despite the non-lethal dose, the colchicine intake led to multiple organ failure. Unlike what is known from a previous report, this patient reached a critical stage in her presentation, which was not related to drug interaction. Colchicine is a therapeutic drug used in the treatment of intestinal Behçet’s disease.
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