Keqian Wu on Muck Rack

Keqian Wu

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Articles

LncPTEC mediated homocysteine accumulation elevates oxidative stress via UBQLN1-dependent MTHFD1 ubiquitination in DKD

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By Qijia Wang, Tianhui Wu, Peiling Li, Rui Peng, Xuemei Peng, Ziyue Lin, Dan Lv, Xiaohui Liao, Yan Sun, Zheng Zhang, He Zha, Keqian Wu, Handeng Liu
| Nature Verified
Abstract Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease and chronic kidney disease. Oxidative stress, a key driver of renal fibrosis and a hallmark of DKD pathological changes, has been extensively studied for its role in DKD progression. However, its specific mechanisms remain unclear. Here, we show that homocysteine (Hcy) accumulation in proximal tubular epithelial cells (PTECs) is a significant contributor to mitochondrial oxidative stress in DKD.
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