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Publisher Correction: Engineered polyketide synthases enable a microbial chassis for recyclable plastics with tunable properties
Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-026-03229-7, published online 27 July 2026. In the version of the article initially published, in Fig. 4a, the second “b-PDK 3” and the second “b-TK 3” labels (under the purple chemical structures) should have been “b-PDK 3′” and “b-TK 3′”, respectively. In Fig. 4b, “4” on the x axis should have been “3′”. In the bottom-right panel of Fig. 4c, “b-PDK 3” and “b-TK 3” should have been “b-PDK 3′” and “b-TK 3′”.
Engineered polyketide synthases enable a microbial chassis for recyclable plastics with tunable properties
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Abstract Plastics derived from fossil feedstocks pose major recycling challenges, particularly crosslinked thermosets used in electronics, construction and composites. Polydiketoenamines (PDKs) are recyclable alternatives; however, monomers such as dimedone are petrochemical-derived and offer limited tunability. We computationally screened 144 β-keto-δ-lactones (BKDLs), identifying solvation free energy as the primary determinant of depolymerization temperature across a 20–60 °C range.
By Zilong Wang, Hai Wang, Jérémy Demarteau, Alexander R. Epstein, Baishakhi Bose, Matthias Schmidt Verified, Leah KEISER, Mei Zhao, Beibei Ge, Alberto Nava, Ramu Kakumanu, Edward Baidoo, Yan Chen, Christopher J. Petzold, Yifan Guo, Nawa Raj Baral, Nemi Vora, Sarah L. Nordahl, Yuzhong Liu, Rithwik Ghanta, Pablo Cruz-Morales, Kevin Yin, Robert W. Haushalter, Kristin Persson, Corinne D. Scown, Brett A. Helms, Jay D. Keasling, Seokjung Cheong, Weixi Hu
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Nature
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