Kevinn Eddy

1 MELANOMA: INCIDENCE AND TYPES Skin cancer is the most prevalent type of cancer in the United States with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the most common types, followed by melanoma (Siegel et al., 2023). BCC and SCC have a lower propensity to metastasize than melanoma and can be curable most of the time by surgeries. In contrast, melanoma accounts for only 1% of all skin cancers, but it is responsible for the majority of deaths from skin cancer.

Introduction During the last decade, an increasing number of immunotherapy approaches have shown clinical benefit for many patients with certain forms of cancer. Many preclinical studies have established that cancer treatment is most effective when several different therapeutic modalities are combined (1–4). We have previously shown that combining local radiotherapy (RT) with immunotherapy can be synergistic in several mouse tumor models (5).