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Khaireen Idzham on Muck Rack

Khaireen Idzham

As seen in: Nature, BioRxiv
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Articles

Evolutionarily conserved role of telomerase reverse transcriptase in programming the microenvironment via regulation of the cGAS–STING pathway - Nature Cell Biology

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By Lele Wu, Khaireen Idzham, Asami Oji, Stefan Oehlers, Masahito Ikawa
| Nature Verified
Abstract Telomerase holoenzyme maintains telomere length and regulates inflammation caused by telomeric DNA damage. However, beyond its role in telomere maintenance, the molecular function of telomerase in directly regulating inflammation remains unclear. Here we show that the reverse transcriptase component of telomerase, TERT, has a cell-type-specific role in directly regulating inflammation via the cytoplasmic cGAS–STING nucleic acid-sensing pathway.
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Retraction Note: Tumour microenvironment programming by an RNA-RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma | Nature Cell Biology

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By Lele Wu, Yong Jae Shin, Yiyun Yin, Khaireen Idzham, Jayantha Gunaratne, Tao Jiang
| Nature Verified
Retraction to: Nature Cell Biology (2024) 26:1003-1018 https://doi.org/10.1038/s41556-024-01428-5 The authors are retracting this Article after concerns over several image irregularities were brought to our attention, including but not limited to the following: In Fig. 1f, there appears to be a partial overlap between the Control siRNA and WWTR1-AS1 siRNA panels; In Fig. 6b, the WT-KO and KO-WT mice appear very similar; In Fig.
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Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma - Nature Cell Biology

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By Lele Wu, Yong Jae Shin, Yiyun Yin, Khaireen Idzham, Jayantha Gunaratne, Tao Jiang
| Nature Verified
Abstract Patients with IDH-wild-type glioblastomas have a poor five-year survival rate along with limited treatment efficacy due to immune cell (glioma-associated microglia and macrophages) infiltration promoting tumour growth and resistance. To enhance therapeutic options, our study investigated the unique RNA–RNA-binding protein complex LOC–DHX15.
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