Khaldun Obeidat on Muck Rack

Khaldun Obeidat

As seen in: Frontiers
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Genomic complexity in advanced gastric and esophageal adenocarcinomas: a case report of rare WDR11-AS1-FGFR2 fusions

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By Dustin A Deming, Jeremy D. Kratz, Lauren Welch, Nataliya V. Uboha, Eric Mehlhaff, Khaldun Obeidat
| Frontiers
Introduction Fibroblast growth factor receptors (FGFRs) are a family of proteins involved in key cellular processes such as proliferation, differentiation, and survival (1). FGFR aberrations are observed across a wide range of cancers, with up to 7.1% of all tumors harboring mutations, fusions, or gene amplifications that result in abnormal FGFR signaling. The prevalence of FGFR alterations is reported in 17-26% of gastric carcinomas and approximately 13% of esophageal carcinomas (1–4).
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