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Khay Guan Yeoh on Muck Rack

Khay Guan Yeoh

As seen in: Nature, Gastrointestinal Endoscopy
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Articles

Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities - Nature Communications

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By May Lee, Srinivasaraghavan Kannan, Choon Seng Chong, Khay Guan Yeoh, Radoslaw M. Sobota, Wai Leong Tam, Jeffrey Lum
| Nature Verified
Abstract Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating tumor suppression, and by conferring pro-carcinogenic activities. We report here that p53 DNA-binding domain (DBD) and transactivation domain (TAD) mis-sense mutants unexpectedly activate pro-carcinogenic epidermal growth factor receptor (EGFR) signaling via distinct, previously unrecognized molecular mechanisms.
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Artificial Intelligence-assisted Treatment Strategy for T1 Colorectal Cancer after Endoscopic Resection

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By Katsuro Ichimasa, Shin-ei Kudo, Tetsuo Nemoto, Khay Guan Yeoh
| Gastrointestinal Endoscopy Verified
This paper is only available as a PDF. To read, Please Download here.
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Mapping the genomic diaspora of gastric cancer - Nature Reviews Cancer

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By Patrick Tan, Khay Guan Yeoh
| Nature Verified
Bray, F. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424 (2018). PubMed PubMed Central Google Scholar GBD 2017 Stomach Cancer Collaborators. The global, regional, and national burden of stomach cancer in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease study 2017. Lancet Gastroenterol. Hepatol. 5, 42–54 (2020). Google Scholar Global Cancer Observatory.
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