Highlights • Toll receptors generate planar-polarized patterns of Src and PI3K activity • Src and PI3K are required for localized myosin contractility and convergent extension • Src kinases promote Toll-2 phosphorylation and Toll-2/PI3K-reg complex formation • Toll-2 phosphorylation is necessary for planar polarity and convergent extension Summary Toll-like receptors are essential for animal development and survival, with conserved roles in innate immunity, tissue patterning, and cell behavior.
