Kihn Luan

Fibromyalgia and opioid use disorder (OUD) are highly burdensome chronic diseases with substantially overlapping psychosocial, neurobiological, and clinical features.9,26,45 Adverse childhood events and trauma during adulthood increase risk of fibromyalgia and OUD, and both conditions commonly co-occur with anxiety and mood disorders.31,32,39,58 Although the pathogenesis of fibromyalgia is incompletely understood, sensitization of the central nervous system to normal or subthreshold...