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Kiki Schraa on Muck Rack

Kiki Schraa

As seen in: Color Research & Application, Wiley, Cell Reports
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Articles by Kiki Schraa

Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects

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By Martin Jaeger, Rob Horst, Kiki Schraa, Jelle Zwaag
| Color Research & Application Verified
Abstract The IL‐1 family member IL‐38 (IL1F10) suppresses inflammatory and autoimmune conditions. Here, we report that plasma concentrations of IL‐38 in 288 healthy Europeans correlate positively with circulating memory B cells and plasmablasts. IL‐38 correlated negatively with age (p = 0.02) and was stable in 48 subjects for 1 year. In comparison with primary keratinocytes, IL1F10 expression in CD19+ B cells from PBMC was lower, whereas cell‐associated IL‐38 expression was comparable.
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Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

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By Lianmin Chen, Rob Horst, Martijn Koehorst, Kiki Schraa
| Cell Reports Verified
Highlights • Plasma bile acid profiles show large inter-individual variability in obesity • Distinct genetic and microbial associations to plasma and fecal bile acid profiles • Plasma secondary bile acids correlate with diabetes and liver fat content • Plasma C4 correlates with features of diabetic dyslipidemia in obesity Summary Bile acids (BAs) are implicated in the etiology of obesity-related conditions such as non-alcoholic fatty liver disease.
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