Kim M. Cecil on Muck Rack

Kim M. Cecil

Seattle
As seen in: Environmental Health Perspectives, Color Research & Application, Nature, Wiley Online Library, National Geographic, BMJ Open, Chemical & Engineering News (C&EN), Newswise, Environmental Health News, The Daily Climate
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Articles

Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial - Nature Medicine

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By Paola Leone, Kim M. Cecil, Olga Flamini
| Nature Verified
Abstract This open-label phase 1/2 clinical study uses a novel recombinant vector, rAAV-Olig001, with selective tropism for oligodendrocytes, to deliver gene therapy for Canavan disease (CD), a rare leukodystrophy characterized by defective aspartoacylase and elevated N-acetyl-aspartic acid (NAA) concentrations. A total of 8 participants received intracranial doses of 3.7 × 1013 vector genomes (vg) of rAAV-Olig001-ASPA (MYR-101), with an interim analysis at 12 months.
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Prenatal Exposure to PBDEs Linked to Adolescent Behavioral Concerns

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By Kim M. Cecil, Kimberly Yolton
| cincinnatichildrens.org
A long-running Cincinnati Children’s study that tracks exposures to environmental toxicants reports that 12-year-old children exposed prior to birth to elevated levels of a common type of flame retardant shows continuing associations with increased behavioral problems. Details were published in April 2024 in Environmental Research.
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Early exposure to flame retardants is prospectively associated with anxiety symptoms in adolescents: A prospective birth cohort study

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By Jeffrey Strawn, Yingying Xu, Kim M. Cecil, Jane Khoury
| Wiley Online Library Verified
1 INTRODUCTION Anxiety disorders, which affect 7%–10% of children and adolescents, are the most common mental health conditions across the age span (Merikangas et al., 2010). They frequently emerge in late childhood and adolescence (Beesdo et al., 2010; Beesdo-Baum & Knappe, 2012) and are associated with significant impairment (Kendall et al., 2010; Ranøyen et al., 2018).
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