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Articles by Kim ND
Sulforaphane in Cancer Prevention and Therapy: A State-of-the-Art Review of Epidemiological Evidence, Molecular Mechanisms, and Translational Challenges.
Abstract <p>Sulforaphane (SFN), an aliphatic isothiocyanate derived from cruciferous vegetables such as broccoli, has emerged as a chemopreventive dietary agent. SFN exerts multifaceted anticancer effects through the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathways, inhibition of histone deacetylases (HDACs) and hypoxia-inducible factor-1α (HIF-1α), and regulation of apoptosis and autophagy.
Cardioprotective effect of resveratrol in myocardial ischemia/reperfusion injury and myocardial infarction: a pre-clinical meta-analysis in animal studies
To investigate the role of RES in the fight against MI and MIRI, 57 articles with 1,125 animals were investigated in this meta-analysis.
Metabolomics profiling reveals differences in proliferation between tumorigenic and non-tumorigenic Madin-Darby canine kidney (MDCK) cells
Na Sun conceived and designed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft. Yuchuan Zhang performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft. Jian Dong performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft. Geng Liu performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft.
Recent Developments in Combination Chemotherapy for Colorectal and Breast Cancers with Topoisomerase Inhibitors
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Hepatocyte-specific knockout of HIF-2α cannot alleviate carbon tetrachloride-induced liver fibrosis in mice
Discussion Liver fibrosis remains an important clinical problem throughout the world. Despite significant advances in understanding the disease, no effective drugs have been developed to directly prevent or reverse the fibrotic process. For many patients, liver transplantation remains the only viable option. Identification of new therapeutic targets that will slow or reverse the progression of fibrosis in such patients is necessary.
Hypoxia-induced factor and its role in liver fibrosis
Introduction Liver fibrosis develops when the liver undergoes any damage or injury and is considered one of the major clinical concerns worldwide. Alcohol consumption, drugs, viral infections, genetic disorders, fatty liver diseases like non-alcoholic, alcoholic fatty liver diseases, and autoimmune hepatitis are major contributing factors to liver injury. Hepatocellular injury caused by all these factors starts a mechanism of reparation.
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