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Kimberlee Kossick on Muck Rack

Kimberlee Kossick

As seen in: BioRxiv
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Articles

Intestinal Stem Cells from Patients with Inflammatory Bowel Disease Retain an Epigenetic Memory of Inflammation

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By Feda H. Hamdan, Isaiah Perez, Kimberlee Kossick, Hannah Smith
| BioRxiv
Abstract Intestinal epithelial damage and impaired repair are hallmarks of ulcerative colitis (UC), even after inflammation resolves. Intestinal stem cells (ISCs) can retain stable epigenetic changes after inflammation, highlighting the potential for long-lived epithelial memory in the gut.
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Intestinal Stem Cells Retain an Epigenetic Memory of Prior Inflammation

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By Feda H. Hamdan, Isaiah Perez, Hannah Smith, Kimberlee Kossick
| BioRxiv
Abstract Background & Aims: Intestinal epithelial damage and impaired repair are hallmarks of ulcerative colitis (UC), even after inflammation resolves. Inflammatory injury in barrier tissues induces epigenetic memory in epithelial stem cells, and the tendency of UC to relapse at previously inflamed sites indicates this imprinting may occur in long-lived cells like intestinal stem cells (ISCs).
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