Skip to main content
Kimberly Joan McCabe on Muck Rack

Kimberly Joan McCabe

As seen in: BioRxiv
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Kimberly Joan

Contact Kimberly Joan, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Synaptic cleft geometry modulates NMDAR opening probability by tuning neurotransmitter residence time

|
By Maria Hernandez Mesa, Kimberly Joan McCabe, Padmini Rangamani
| BioRxiv
Abstract Synaptic morphology plays a critical role in modulating the dynamics of neurotransmitter diffusion and receptor activation in interneuron communication. In this study, we investigated how variations in synaptic geometry, including curvature of the synaptic cleft, distance between the presynaptic and postsynaptic membranes, and the surface area- to-volume ratio of the cleft, influence glutamate diffusion and N-Methyl-D-Aspartate receptor (NMDAR) opening probabilities.
Open in Who Shared Issue with article?

Spine apparatus modulates Ca2+ in spines through spatial localization of sources and sinks

|
By Frédéric J. Hoerndli, Maria Hernandez Mesa, Guadalupe Clara Garcia, Kimberly Joan McCabe
| BioRxiv
Abstract Dendritic spines are small protrusions on dendrites in neurons and serve as sites of postsynaptic activity. Some of these spines contain smooth endoplasmic reticulum (SER), and sometimes an even further specialized SER known as the spine apparatus (SA). In this work, we developed a stochastic spatial model to investigate the role of the SER and the SA in modulating Ca2+ dynamics.
Open in Who Shared Issue with article?
See all 2 articles