Kin Ho Chan on Muck Rack

Kin Ho Chan

As seen in: Nature, Wiley Online Library
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Articles

Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c

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By Pavel Mader, Linshan Liu, Frédéric Vallée, François Denis, Daniel Mao, Lauren Caldwell, Kin Ho Chan, Igor Kurinov, Zemin Zhang, Mike Tyers, W. Black, Michael Zinda, Daniel Durocher, Jeff Wrana, Michal Zimmermann, Frank Sicheri, Victor Pau, Yael Mamane, Paranjay Parikh, Michel Gallant
| Nature Verified
Abstract Lysine demethylase 2A (KDM2A) is a key epigenetic regulator and promising target for inhibition since its loss is selectively lethal in cancers reliant on Alternative Lengthening of Telomeres (ALT). Here we investigated the mechanism of compound 183c, a potent KDM2A inhibitor described in the patent literature. Biophysical studies showed that 183c requires the co-factor 2-oxoglutarate (2OG) for binding.
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Impact of Nutrient Limitation on Nezara viridula Development: Validation of a Stage‐Structured Degree‐Day Model in Outdoor and Greenhouse Environments Using Citizen Science Data

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By Rob Moerkens, Kin Ho Chan, Stijn Bellinkx, Kristijn Swinnen
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. References , and . 1977. “Photoperiodic and Temperature Effects on Rate of Development and Diapause in the Green Stink Bug, Nezara viridula L. (Heteroptera: Pentatomidae).” Zeitschrift für Angewandte Entomologie 84: 256–264. , , and . 1979. “A Study on the Phenology and Ecology of the Green Stink Bug Nezara viridula L. (Heteroptera: Pentatomidae).” Journal of Applied Entomology 88: 476–483. , and . 2010.
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Data‐driven approach to weekly forecast of the western flower thrips (Frankliniella occidentalis Pergande) population in a pepper greenhouse with an ensemble model

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By Kin Ho Chan, Rob Moerkens, Nathalie Brenard, Marlies Huysmans
| Wiley Online Library Verified
Table S2. Description of growing and sampling settings for 2017 and 2018 data. Figure S1. The temporal autocorrelation for Frankliniella occidentalis and Macrolophus pygmaeus of each compartment (blue dots: F. occidentalis; red dots: M. pygmaeus). Figure S2. The temporal partial autocorrelation for Frankliniella occidentalis and Macrolophus pygmaeus of each compartment (blue dots: F. occidentalis; red dots: M. pygmaeus). Table S4.
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