Kioa L. Wijnsma

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Although no official document or international guideline directly addresses the duration of eculizumab therapy, it is assumed (and advocated in various scientific meetings and publications) that standard therapy is eculizumab in two weekly dosages lifelong [1, 15]. Indeed approval reports of both EMA and FDA emphasize the risks of withdrawal of eculizumab [15, 16, 17]. In most guidelines, both treatment duration and dosage of eculizumab are debated [1, 15].