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KIONET Augsburg Germany

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Malignant Rhabdoid Tumors of Cranial Nerves-A Clinically Distinct Group With Characteristic Neuroradiological, Histopathological, and Molecular Features - Gruhle - Pediatric Blood & Cancer - Wiley Online Library

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By Brigitte Bison, Katharina Gastberger, Miriam Gruhle, KIONET Augsburg Germany
| Wiley Online Library Verified
AT/RT atypical teratoid/rhabdoid tumor MRT malignant rhabdoid tumor RTK rhabdoid tumor of the kidney 1 Introduction Malignant rhabdoid tumors (MRT) are aggressive malignancies predominantly affecting children below 3 years of age, which are defined by mutations affecting SMARCB1 or (rarely) SMARCA4, causing loss of protein expression of chromatin remodeling complex members SMARCB1/INI1 or SMARCA4/Brg1, respectively [1]. Despite aggressive therapy, the outcome of many patients remains poor [2, 3].
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