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Kira Devantier

As seen in: British Pharmacological Society, Science Magazine
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Articles by Kira Devantier

The SH protein of mumps virus is a druggable pentameric viroporin

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By Brandon M. Genco, Yanni Schneider, Janko Kajtez, Kira Devantier, Trine L. Toft-Bertelsen, Andreas Prestel, Cagla Sahin, Marco Giulini, Stavroula F. Louka, Katja Spiess, Asmita Manandhar, Katrine Qvortrup, Trond Ulven, Bo H. Bentzen, Alexandre MJJ Bonvin, Nanna MacAulay, Birthe B. Krage
| Science Magazine Verified
Abstract Viral infections are on the rise and drugs targeting viral proteins are needed. Viroporins constitute a growing group of virus-encoded transmembrane oligomeric proteins that allow passage of small molecules across the membrane. Despite sparsity in viroporin structures, recent work has revealed diversity in both the number of transmembrane helices and oligomeric states. Here, we provide evidence that the small hydrophobic protein (SH) from mumps virus is a pentameric viroporin.
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Advancing the field of viroporins-Structure, function and pharmacology: IUPHAR Review 39

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By Kira Devantier, NMR Metabolomics Laboratory, Stephen Griffin, Birthe B. Kragelund
| British Pharmacological Society
2BCVB3 coxsackievirus B3 2B 2BHAV hepatitis A virus 2B 2BPV poliovirus 2B 3aSARS-CoV-2 SARS-CoV-2 3a 6KCHIKV chikungunya virus 6K 6KRRV Ross river virus 6K CD-M2IAV conductance domain M2IAV E5HPV human papillomavirus E5 ESARS-CoV-1 severe acute respiratory coronavirus 1 E protein ESARS-CoV-2 severe acute respiratory coronavirus 2 E protein HMA hexamethylene amiloride IAV influenza A virus KcvPBCV-1 Paramecium bursaria chlorella virus 1 Kcv M2IAV influenza A virus M2 M2IBV influenza B virus M2...
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