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Quantitative Guanidinium CEST-Based pH Mapping at 3 T in Healthy and Pathological Muscle
BM Bloch–McConnell CEST chemical exchange saturation transfer Cr creatine FF fat fraction f guan2.0 guanidinium proton fraction at 2.0 ppm GL gastrocnemius lateralis GM gastrocnemius medialis k ex,guan2.0 guanidinium protons exchange rate at 2.0 ppm MRS magnetic resonance spectroscopy MT magnetization transfer PCr phosphocreatine PER peroneus longus SOL soleus TA tibialis anterior 1 Introduction Quantitative MRI (qMRI) and MRS muscular biomarkers are used in many longitudinal studies in...
Extreme multivalency and a composite short linear motif facilitate PCNA‐binding, localisation and abundance of p21 (CDKN1A)
APIM AlkB homologue 2 PCNA-interacting motif APSB adaptive Poisson-Boltzmann solver CDK cyclin-dependent kinase CDKN1 cyclin-dependent kinase inhibitor 1 ESM evolutionary scale modelling IDP intrinsically disordered protein IDR intrinsically disordered region IRES internal ribosome entry site ITC isothermal titration calorimetry NLS nuclear localisation signal NMR nuclear magnetic resonance PCNA proliferating cell nuclear antigen PIP PCNA-interacting protein PQC protein quality control...
Hierarchy in regulator interactions with distant transcriptional activation domains empowers rheostatic regulation
1 INTRODUCTION Intrinsically disordered regions (IDRs) are conformationally malleable, empowering them with an enormous interaction potential in protein networks (Holehouse & Kragelund, 2023) and responsiveness to cellular cues through post-translational modifications (Newcombe et al., 2022) and interactions (Bjarnason et al., 2023).
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