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Kirill Lotonin on Muck Rack

Kirill Lotonin

As seen in: BioRxiv, eLife
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Articles

Correlates of protection against African swine fever virus identified by a systems immunology approach

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By Kirill Lotonin, Francisco Brito, Kemal Mehinagic
| eLife
eLife Assessment This study provides valuable findings regarding potential correlates of protection against the African swine fever virus. The evidence supporting the claims is solid, and the results are highly relevant to the field. Further analysis using larger number of animals and other virus strains will help validate the importance of these findings and assess the relevance of the immune parameters associated with protection.
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Correlates of protection against African swine fever virus identified by a systems immunology approach

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By Francisco Brito, Kemal Mehinagic, Obdulio García-Nicolás, Kirill Lotonin
| BioRxiv
Abstract African swine fever virus (ASFV) causes a fatal hemorrhagic disease in domestic pigs and wild boars, which poses severe threats to the global pork industry. Despite the promise of live attenuated vaccines (LAVs), their narrow margin between efficacy and residual virulence presents major safety challenges. This study bridges a critical knowledge gap in ASF vaccinology by identifying innate and adaptive correlates of protection.
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