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Kirtana Arikath on Muck Rack

Kirtana Arikath

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Articles

Distinct glycosyltransferase expression governs organ-specific survival in pancreatic cancer metastasis

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By Venkatesh Varadharaj, Frank Leon, Palanisamy Nallasamy, Pratima Raut, Wyatt Petersen, Sanchita Rauth, Poompozhil Mathivanan, Saravanakumar Marimuthu, Jesse Cox, Geoffrey A Talmon, Paul M. Grandgenett, Michael A Hollingsworth, Dominick J. DiMaio, Jean L. Grem, Surinder K. Batra, Moorthy P. Ponnusamy, Nivedeta Krishna Kumar, Annant Bir Kaur, Kirtana Arikath, Neelanjana Gayen, Zahraa Wajih Alsafwani, Kavita Mallya, Madhu Bommideni
| Nature Verified
Abstract Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, with over 83% of patients presenting metastases to vital organs such as the liver, lungs, and peritoneum. Although glycosylation has been established as a critical factor in PDAC development, little is known about the molecular underpinnings of organ-specific metastasis. In this study, we investigated the role of glycosyltransferases (GTs) in mediating PDAC metastatic organotropism.
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