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Klavdija Krause

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Articles

Ablation of CDK6 and STAT5B rewires T cell developmental dynamics and prevents ALK + lymphoma formation

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By Jonatan Kendler, Barbara Maurer, Dua Shahid, Alexander Pichler, Tania Brandstoetter, Michaela Prchal-Murphy, Stefania Massari, Lukas Kenner, Richard Moriggl, Philipp B. Staber, Veronika Sexl, Sebastian Kollmann, Karoline Kollmann, Thorsten Klampfl, Maximilian Sexl, Alessia Schirripa, Elisabeth Gamper, Hager El Kersh, Reinhard Grausenburger, Klavdija Krause, Giorgia Damonte, Sabine Lagger
| Nature Verified
Abstract CDK6 and STAT5B are well-established oncogenic drivers, but their interplay during transformation remains poorly understood. Here, we demonstrate that simultaneous genetic deletion of Cdk6 and Stat5b in an NPM-ALKTg/+ mouse model completely prevents tumor formation. Immature DN2/3 thymocytes are identified as the cellular origin of ALK-driven malignancy.
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