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Loading metrics Open Access Peer-reviewed Research Article Citation: Kubo H, Moriyama M, Goto S, Miyake Y, Nakamura M, Ozeki Y, et al. (2025) Sage extract and ascorbic acid derivative inhibit melanogenesis via downregulating keratinocyte-derived GM-CSF. PLoS One 20(6): e0325242. https://doi.org/10.1371/journal.pone.0325242 Editor: Anju George, Christian Medical College Vellore, INDIA Received: February 10, 2025; Accepted: May 10, 2025; Published: June 10, 2025 Copyright: © 2025 Kubo et al.