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Koby Baranes

As seen in: BioRxiv
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Articles

Circadian clocks in human cerebral organoids

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By Nina M Rzechorzek, Magdalena Sutcliffe, Andrei Mihut, Koby Baranes
| BioRxiv
Abstract Circadian rhythms result from cell-intrinsic timing mechanisms that impact health and disease1,2. To date, however, neural circadian research has largely focused on the hypothalamic circuitry of nocturnal rodents3. Whether circadian rhythms exist in human brain cells is unknown. Here we show bona fide circadian rhythms in human neurons, glia, cerebral organoids, and cerebral organoid slices (ALI-COs)4-8.
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