Kodye Abbott

Supporting information (A) Plots portraying predicted drug dose response curves, with active RAF protomers as the readout. Multiple levels of 14-3-3 expression in the CAS + DS model are shown. Active RAF is shown normalized to the drug free level (above) and to the percent of total RAF (below) for the same conditions as Fig 2B. (B) Plots portraying how 14-3-3 proteins would influence total RAF dimers when only the CAS mechanism, only the DS mechanism, or both CAS and DS mechanisms are considered.

Abstract Mathematical models of biochemical reaction networks are an important and emerging tool for the study of cell signaling networks involved in disease processes. One promising potential application of such mathematical models is the study of how disease-causing mutations promote the signaling phenotype that contributes to the disease.