Kohen Goble on Muck Rack

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Articles

Leveraging AI to Automate Detection and Quantification of Extrachromosomal DNA (ecDNA) to Decode Drug Responses

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By Jacob Fessler, Kohen Goble, Aarav Mehta, Damien Guilbaud
| biorxiv.org
Abstract Traditional drug discovery efforts have largely focused on targeting rapid, reversible protein-mediated adaptations to undermine cancer cells' resistance to therapy. However, cancer cells also exploit DNA-based strategies, typically viewed as slow, irreversible, and unpredictable changes like point mutations or the selection of drug-resistant clones.
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