Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Koichi Node
Hypertensive stress rewires macrophage signaling in heart failure with preserved ejection fraction independent of obesity
Abstract Heart failure with preserved ejection fraction (HFpEF) remains a major unmet clinical challenge. Although obesity is common in many HFpEF cohorts from Europe and North America, three Japanese HFpEF cohorts identified hypertension and sympathetic overactivation, rather than obesity, as dominant features.
Blood pressure and cardiovascular risk in adults with non-proteinuric chronic kidney disease without diabetes
Abstract We investigated the association between blood pressure (BP) and the risk of cardiovascular disease (CVD) in individuals with non-proteinuric chronic kidney disease (CKD) without diabetes. Using a large-scale nationwide administrative claims and health checkup database in Japan, we identified 287,238 non-diabetic adults with an estimated glomerular filtration rate <60 mL/min/1.73 m2 and negative/trace proteinuria.
Cardiovascular events with esaxerenone versus spironolactone in hypertension
Abstract Mineralocorticoid receptor antagonists (MRAs) exhibit distinct pharmacologic profiles, yet their differential clinical relevance remains underexplored. This study assessed cardiovascular prevention with nonsteroidal esaxerenone (ESAX) relative to steroidal spironolactone (SPL) in hypertensive populations. From a nationwide claims database, we identified individuals with hypertension who newly initiated ESAX or SPL.
Prediction model for aortic dissection, aortic aneurysm, and peripheral artery disease
Abstract Aortic dissection (AD), aortic aneurysm (AA), and peripheral artery disease (PAD) are associated with higher mortality. However, validated prediction models for these conditions remain scarce. We developed risk prediction models for AD, AA, and PAD using routine health check-up data. We used data from the DeSC database, encompassing 1,082,369 participants aged 20–74 years without prior cardiovascular disease for model derivation.
In Response to “Quantifying the population burden of hypertension: methodological considerations on the PAF analysis of the DeSC cohort”
|
We would like to thank Dr. Tian Ruan for carefully reading our recent publication and providing insightful commentary on ourrecent publication, “Population attributable fraction of modifiable risk factors for incident hypertension: an analysis of large-scale epidemiological cohort” [1, 2]. We deeply appreciate the opportunity to address these valuable methodological considerations, which indeed complement and strengthen the interpretation of our findings.
By Masachika Nishikawa, Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Norifumi Takeda, Hiroyuki Morita, Katsuhito Fujiu, Tatsuhiko Azegami, Kaori Hayashi, Kaori Kitaoka, Katsuyuki Miura, Atsushi Mizuno, Akihiro Nomura, Kazuomi Kario, Koichi Node, Hideo Yasunaga, Masaomi Nangaku, Hisatomi Arima, Norihiko Takeda
|
Nature
Verified
Post hoc analysis of SURMOUNT-J: tirzepatide versus placebo and predicted 10-year cardiovascular disease risk in Japanese adults with obesity disease
Abstract Objective Obesity management is central to reducing cardiovascular disease (CVD) risk. In the phase 3 SURMOUNT-J trial, tirzepatide significantly reduced body weight and improved cardiometabolic parameters versus placebo in Japanese adults with obesity disease (as defined by the Japan Society for the Study of Obesity [JASSO], referring to obesity requiring clinical treatment) and without diabetes.
Effect of population-approach programs promoting salt reduction and potassium intake in Japan: the Population-based Sodium/Potassium Improvement Program (PoSPIP)
Abstract Reducing sodium intake in populations is essential, but insufficient for preventing and managing high blood pressure, while the importance of increasing potassium intake is overlooked. We investigated the effects of 1-year population-approach programs (2021–2022) promoting salt reduction and potassium intake using urinalysis feedback and food environment improvement.
In Response to “Is low lean body mass a risk factor for hypertension?”
Response to Letter to the Editor We thank Tabara for the thoughtful comments regarding the interpretation of lean body mass index (LBMI) in relation to body mass index (BMI) [1]. In our study of 384,551 men, we demonstrated that lower LBMI—estimated from height, weight, and waist circumference—was associated with a higher risk of incident hypertension [2].
Guidelines for the appropriate use of renal denervation systems in Japan: endorsed by the Japanese Society of Hypertension (JSH), the Japanese Association of Cardiovascular Intervention and Therapeutics (CVIT), and the Japanese Circulation Society (JCS),
Abstract This document presents the Guidelines for the Appropriate Use of Renal Denervation (RDN) Systems in Japan, jointly endorsed by the Japanese Society of Hypertension (JSH), the Japanese Association of Cardiovascular Intervention and Therapeutics (CVIT), and the Japanese Circulation Society (JCS). Based on the final consensus statement of the Joint Committee on RDN, these guidelines identify resistant hypertension as the principal indication for RDN treatment in Japan.
Epidemiological and clinical evidence on blood pressure management for the prevention of dementia: striving for a healthy 100-year life
|
Abstract As Japan faces rapid population aging, understanding modifiable risk factors for dementia is critical. This review explores the impact of hypertension and blood pressure (BP) management on dementia onset. Midlife hypertension emerges as a key risk factor, especially for vascular dementia, while late-life BP effects are variable. Observational studies suggest a critical window for intervention between ages 55–74. Moreover, BP variability independently predicts cognitive decline.
By Shintaro Ishida, Miki Kawazoe, Takako Fujii, Yori Inoue, Koichi Yamamoto, Taku Inoue, Toshiharu Ninomiya, Yoichi Nozato, Takuro Kubozono, Hiroshi Akasaka, Eiichiro Yamamoto, Michiaki Nagai, Masafumi Ihara, Yoichi Takami, Shuko Takeda, Toru Yamashita, Shigeru Shibata, Koichi Node, Kazuomi Kario, Masaki Mogi, Hisatomi Arima, Atsushi Sakima, Takahiro Komori, Yume Nohara
|
Nature
Verified
Population attributable fraction of modifiable risk factors for incident hypertension: an analysis of large-scale epidemiological cohort - Hypertension Research
|
Abstract Identifying and prioritizing modifiable risk factors is crucial for the primary prevention of hypertension. However, large-scale data on the population attributable fraction (PAF) for a comprehensive range of modifiable risk factors for incident hypertension in the Japanese population have been scarce. This study analyzed 1,069,948 participants (median age 56, 43.7% men) without a history of hypertension from the DeSC database.
By Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Norifumi Takeda, Hiroyuki Morita, Katsuhito Fujiu, Tatsuhiko Azegami, Kaori Hayashi, Kaori Kitaoka, Katsuyuki Miura, Atsushi Mizuno, Akihiro Nomura, Kazuomi Kario, Koichi Node, Hideo Yasunaga, Masaomi Nangaku, Hisatomi Arima, Norihiko Takeda, Masachika Nishikawa
|
Nature
Verified
In response to lean body mass index and hypertension risk in men: a nationwide epidemiological cohort study - Hypertension Research
Response to Letter to the Editor We thank Wang and Shao for their interest in our study and for their constructive comments regarding statistical methodology [1]. Our article titled “Lean body mass index (LBMI) and hypertension risk in men: a nationwide epidemiological cohort study.” reported that a lower LBMI, estimated using height, weight, and waist circumference, was independently associated with an increased risk of incident hypertension in a large cohort of 384,551 men [2].
Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population - Nature Communications
|
By Nobuyuki Enzan, Satoshi Koyama, Hirotaka Ieki, Kouichi Ozaki, Yoshihiro Onouchi, Koichi Matsuda, Yukihide Momozawa, Hiroyuki Aburatani, Yoichiro Kamatani, Takanori Yamaguchi, Hiroshi Akazawa, Koichi Node, Patrick T. Ellinor, Michael Levin, Scott M. Damrauer, Benjamin F Voight, Jacob Joseph, Yan Sun, Chikashi Terao, Toshiharu Ninomiya
|
Nature
Verified
Age-Dependent Relationship of Physical Inactivity with Incident Cardiovascular Disease: Analysis of a Large Japanese Cohort
ABSTRACT There have been limited studies examining age-dependent associations between physical inactivity and cardiovascular disease (CVD). We aimed to clarify the age-dependent relationship of physical inactivity with incident CVD. We analyzed 1,097,424 participants aged 18-105 years without a history of CVD enrolled in the DeSC database (median age, 63 years; 46.4% men).
Long-term kidney outcomes of semaglutide in obesity and cardiovascular disease in the SELECT trial - Nature Medicine
Abstract The SELECT trial previously reported a 20% reduction in major adverse cardiovascular events with semaglutide (n = 8,803) versus placebo (n = 8,801) in patients with overweight/obesity and established cardiovascular disease, without diabetes. In the present study, we examined the effect of once-weekly semaglutide 2.4 mg on kidney outcomes in the SELECT trial.
Detection of endogenous circadian rhythms of clock gene mRNA expression in mouse lung tissue using slice cultures
Save citation to file Format: Add to My Bibliography Your saved search Name of saved search: Search terms: Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Create a file for external citation management software
Xanthine oxidase inhibition for cardiovascular disease prevention
In the metabolic process of purine degradation into uric acid, activated xanthine oxidase produces oxygen species and causes a pro-inflammatory vascular state, resulting in an increased risk of cardiovascular disease. 1 Schuchardt M Herrmann J Tolle M van der Giet M Xanthine oxidase and its role as target in cardiovascular disease: cardiovascular protection by enzyme inhibition?.
Fluid volume regulation in patients with heart failure
SGLT2 inhibitors have been shown to reduce the risk of heart failure-related events in a broad range of patients with type 2 diabetes, irrespective of previous history of heart failure. Furthermore, the DAPA-HF and EMPEROR-Reduced trials consistently demonstrated clinical benefits of SGLT2 inhibitors, specifically in stable patients with heart failure with reduced ejection fraction, irrespective of diabetes status.
Suspected Borderline Aldosteronism in Hypertension
Journal of the American College of Cardiology Letters Atsushi Tanaka, Hirotaka Shibata and Koichi Node This article requires a subscription or purchase to view the full text. If you are a subscriber or member, click the login link or the subscribe link in the top menu above to access this article. Author + information This article requires a subscription or purchase to view the full text. If you are a subscriber or member, click Login or the Subscribe link (top menu above) to access this article.
Author Correction: Randomized Evaluation of Anagliptin vs Sitagliptin On low-density lipoproteiN cholesterol in diabetes (REASON) Trial: A 52-week, open-label, randomized clinical trial
Correction to: Scientific Reports https://doi.org/10.1038/s41598-019-44885-x, published online 12 June 2019 This Article contains errors. The calculation method of LDL-C, presented in Figure 2 and 3 is described as being based on the Friedewald (F) equation. However, the data presented was calculated based on the direct method. The correct Figures 2 and 3 appear below as Figures 1 and 2. Figure 1 Change in Low-density Lipoprotein-cholesterol calculated by F equation.
A reduction of BMI predicts the risk of rehospitalization and cardiac death in non-obese patients with heart failure
Publication HistoryPublished online: August 18, 2018Accepted: August 17, 2018; Received in revised form: July 2, 2018; Received: March 27, 2018;
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Koichi
Contact Koichi, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack