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A simple three-dimensional hydrogel platform enables ex vivo cell culture of patient and PDX tumors for assaying their response to clinically relevant therapies

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By Christopher Wheeler, Kolin C Hribar, Alexey Bazarov, Kunal Varshneya
| mct.aacrjournals.org
Research Article Kolin C Hribar, Christopher J Wheeler, Alexey Bazarov, Kunal Varshneya, Ryosuke Yamada, Padraig Buckley and Chirag G Patil DOI: 10.1158/1535-7163.MCT-18-0359 Abstract A cell culture platform that enables ex vivo tissue growth from patients or patient-derived xenograft (PDX) models and assesses sensitivity to approved therapies (e.g. Temozolomide, TMZ) in a clinically relevant timeframe would be very useful in translational research and personalized medicine.
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