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Komaldeep Kaur Kang

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Articles

Transposable elements shape stemness in normal and leukemic hematopoiesis

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By Giacomo Grillo, Bettina Nadorp, Aditi Qamra, Bryce Drylie, Amanda Mitchell, Christopher Arlidge, Ankita Nand, Naoya Takayama, Alex Murison, Andrea Arruda, Jean Wang, Mark D. Minden, Özgen Deniz, Helena Boutzen, John Dick, Mathieu Lupien, Komaldeep Kaur Kang
| Nature Verified
Abstract Despite most acute myeloid leukemia (AML) patients achieving complete remission after induction chemotherapy, two-thirds relapse within 5 years. AML follows a cellular hierarchy sustained by leukemia stem cells (LSCs), which drive tumor progression and relapse. Little is known about the genetic determinants driving LSCs stemness properties.
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