Komgrid Charngkaew on Muck Rack

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Hypercalcemia induces targeted autophagic degradation of aquaporin-2 at the onset of nephrogenic diabetes insipidus

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By Sookkasem Khositseth, Komgrid Charngkaew, Chatikorn Boonkrai, Poorichaya Somparn
| kidney-international.org
Hypercalcemia can cause renal dysfunction such as nephrogenic diabetes insipidus (NDI), but the mechanisms underlying hypercalcemia-induced NDI are not well understood. To elucidate the early molecular changes responsible for this disorder, we employed mass spectrometry–based proteomic analysis of inner medullary collecting ducts (IMCD) isolated from parathyroid hormone–treated rats at onset of hypercalcemia-induced NDI.
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