Kongwen Lin on Muck Rack

Kongwen Lin

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Articles

NINJ1 ubiquitination by TRIM72 protects against plasma membrane rupture and AKI-CKD progression

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By Keng Ye, Siyi Lin, Caiming Chen, Zhimin Chen, Guoping Li, Huabin Ma, Jianfeng Wu, Tak W. Mak, Li Chen, Yanfang Xu, Kongwen Lin
| Nature Verified
Abstract The progression of acute kidney injury (AKI) to chronic kidney disease (CKD) remains a major clinical challenge. It is primarily triggered by renal tubular epithelial cell (RTEC) death that leads to persistent sterile inflammation, maladaptive repair and irreversible renal fibrosis. A pivotal event in RTEC death is plasma membrane rupture (PMR), which leads to the release of Damage-Associated Molecular Patterns (DAMPs).
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