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Kongying Hu on Muck Rack

Kongying Hu

As seen in: Nature, BioRxiv
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Articles

Structural and functional insights into HBx–Smc6 targeting for HBV inhibition

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By Jinhong Zhou, wenjun Huang, Lili Du, Pengyu He, Yan Gao, Kongying Hu, Jieliang Chen, Hongxia wang, Zihe Rao, Zhenghong Yuan, Lanfeng Wang, Renzheng Yang, Menghan Hao
| Nature Verified
Dear Editor, Hepatitis B virus (HBV) infection remains a major global health challenge, affecting over 250 million people worldwide.
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RNAi-mediated HBV antigen shutdown enhances the antiviral immune effects of PEGIFNalpha via altering T and B cell crosstalk

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By Mengying He, Ziyang Song, Wenjing Zai, Kongying Hu
| BioRxiv
Abstract PEGylated interferon-alpha (PEGIFNalpha) demonstrates promising therapeutic outcomes against chronic hepatitis B (CHB), whereas patient response to PEGIFNalpha therapy remains unsatisfied. Shutdown of hepatitis B virus (HBV) antigens by RNA interference (RNAi) could enhance PEGIFNalpha efficacy in CHB patients, whereas the underlying immunological mechanisms remain obscure. We performed studies by utilizing our newly established extracellular humanized IFNAR (IFNAR-hEC) mice.
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