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Konstantinos Nakos

As seen in: Nature, Cell Press
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Articles by Konstantinos Nakos

Motors use biased diffusion to shepherd diffusible proteins on microtubules

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By Leila Farhadi, Shane Fiorenza, Sithara S Wijeratne, Konstantinos Nakos, Yang Yue, Morgan L Pimm, Jakia Jannat Keya, Kristen J. Verhey, Radhika Subramanian, Meredith D. Betterton
| Nature Verified
Abstract Far-from-equilibrium mixtures of active and passive molecules self-organize, but the principles remain unclear. Microtubules are cytoskeletal polymers composed of 13 protofilaments bound by mixtures of actively moving motors and passively diffusing microtubule-associated proteins (MAPs). They can serve as a model system for self-organization on a multi-lane lattice.
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Cellular functions of actin- and microtubule-associated septins

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By Elias T. Spiliotis, Konstantinos Nakos
| Cell Press Verified
Mostowy S. Cossart P. Septins: the fourth component of the cytoskeleton. Nat. Rev. Mol. Cell Biol. 2012; 13: 183-194 Spiliotis E.T. McMurray M.A. Masters of asymmetry - lessons and perspectives from 50 years of septins. Mol. Biol. Cell. 2020; 31: 2289-2297 Woods B.L. Gladfelter A.S. The state of the septin cytoskeleton from assembly to function. Curr. Opin. Cell Biol. 2021; 68: 105-112 Dolat L. Hu Q. Spiliotis E.T. Septin functions in organ system physiology and pathology. Biol. Chem.
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A Septin Double Ring Controls the Spatiotemporal Organization of the ESCRT Machinery in Cytokinetic Abscission

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By Daniel H. Hwang, Jonathan Bowen, Eva P. Karasmanis, Konstantinos Nakos
| Cell Press Verified
Highlights • Septins form a membrane-bound double ring in the midbody of telophase cells • Septin rings demarcate the membrane sites of ESCRT-III assembly • SEPT9 is required for ESCRT-III ring formation and expansion to cones • SEPT9 interacts with TSG101 for recruitment and assembly of ESCRT-II/-III subunits Summary Abscission is the terminal step of mitosis that physically separates two daughter cells [, ].
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