Korkmaz Yilmaz

Abstract Objective: Conventional anthropometric measures may inadequately capture metabolically relevant fat redistribution in hypercortisolism. We evaluated the discriminative performance of clinical indices (Hepatic Steatosis Index [HSI], Visceral Adiposity Index [VAI], Metabolic Score for Visceral Fat [METS-VF]) and anthropometric measures (body mass index [BMI], waist circumference) for MRI-defined visceral adiposity across the hypercortisolism spectrum.

Abstract Background: Achieving physiologic glucocorticoid replacement in adrenal insufficiency (AI) remains challenging, as both under- and over-replacement contribute to morbidity. Hair cortisol concentration (HCC) reflects cumulative cortisol exposure and may provide clinically relevant information beyond single-time-point assessments. Methods: In this cross-sectional study, 64 adults with hydrocortisone-treated AI and 64 matched healthy controls were evaluated.

1 Introduction Cushing’s syndrome (CS) is a rare but complex endocrine disorder resulting from chronic exposure to excess glucocorticoids, most frequently due to adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas or adrenal tumors (1). A broad range of physical, metabolic, and psychiatric manifestations characterizes the clinical phenotype. Clinically, patients typically present with central obesity, muscle atrophy, hypertension, diabetes mellitus, and dyslipidemia (2).