Korrakod Petsri on Muck Rack

Korrakod Petsri

As seen in: Nature, MDPI
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Articles

DH_27, a right-half derivative of renieramycin T, induce apoptosis through inhibition of mTOR signaling for lung cancer suppression

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By Korrakod Petsri, Masashi Yokoya, Satapat Racha, Zin Zin Ei, Daiki Hotta, Naoki Saito, Pinkawas Kongmalai, Pithi Chanvorachote, Rikako Yamashita
| Nature Verified
Abstract Inhibition of mTOR signaling pathway gains a lot of interests as promising strategies for cancer treatment. Recently, we have reported the anticancer potential of the other renieramycin T (RT) right-half compounds. The subsequent modifications were conducted to identify a novel compound capable of exerting anticancer activity through the inhibition of survival proteins and anti-apoptotic proteins.
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Marine Drugs | Free Full-Text | Light-Mediated Transformation of Renieramycins and Semisynthesis of 4′-Pyridinecarbonyl-Substituted Renieramycin-Type Derivatives as Potential Cytotoxic Agents against Non-Small-Cell Lung Cancer Cells

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By Suwimon Sinsook, Koonchira Buaban, Iksen Iksen, Korrakod Petsri
| MDPI
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IJMS | Free Full-Text | Novel Synthetic Derivative of Renieramycin T Right-Half Analog Induces Apoptosis and Inhibits Cancer Stem Cells via Targeting the Akt Signal in Lung Cancer Cells

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By Korrakod Petsri, Masashi Yokoya, Satapat Racha, Sunisa Thongsom
| MDPI
Abstract : Akt is a key regulatory protein of cancer stem cells (CSCs) and is responsible for cancer aggressiveness and metastasis. Targeting Akt is beneficial for the development of cancer drugs. renieramycin T (RT) has been reported to have Mcl-1 targeting activity, and the study of the structure-activity relationships (SARs) demonstrated that cyanide and the benzene ring are essential for its effects.
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