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Articles

Effect of Metal Doping on the Catalytic Activity of MoS2: Access to High-Spin Co (III) Species In Situ toward the Synthesis of Bisindolylmethanes and a Study of Their Bioactivity

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By Komal Jaiswal, Koyel Roy, Mrinmoy De
| dx.doi.org
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An unusual activity of mycobacterial MutT1 Nudix hydrolase domain as a protein phosphatase regulates nucleoside diphosphate kinase (NDK) function

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By Koyel Roy, Devendra Singh, Deepak Saini, Umesh Varshney
| BioRxiv
Abstract MutT proteins are Nudix hydrolases characterized by the presence of a Nudix box, GX5EX7REUXEEXGU, where U is a bulky hydrophobic residue and X is any residue. Major MutT proteins hydrolyse 8-oxo-(d)GTP (8-oxo-GTP or 8-oxo-dGTP) to the corresponding 8-oxo-(d)GMP, preventing their incorporation into nucleic acids. Mycobacterial MutT1 comprises an N-terminal domain (NTD) harbouring the Nudix box motif, and a C-terminal domain (CTD) harbouring the RHG histidine phosphatase motif.
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