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Krishanan Raghunathan on Muck Rack

Krishanan Raghunathan

As seen in: BioRxiv
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Articles

A niche-dependent redox rheostat regulates epithelial stem cell fate in the distal colon

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By Xi Chen, Krishanan Raghunathan, Bin Bao, Elsy M. Ngwa
| BioRxiv
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A niche-dependent redox rheostat regulates epithelial stem cell fate in the distal colon

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By Xi Chen, Bin Bao, Elsy M. Ngwa, Krishanan Raghunathan
| BioRxiv
Abstract The intestinal epithelium is a rapidly regenerating tissue dependent on resident stem cell self-renewal and differentiation. The reactive oxygen species (ROS) generating enzyme NADPH oxidase 1 (NOX1) is spatially restricted to the crypt base epithelium in the distal colon.
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