Krishanu Saha on Muck Rack

Krishanu Saha

Madison
As seen in: Medium, Nature, The Guardian, Scientific American, STAT, Stem Cell Reports, Issues in Science and Technology, Cell & Gene Therapy Insights
Professor at Univ. of Wisconsin-Madison (@WIDiscovery @HoltzCenter @Forward_BIO @UWMadGIE) + Genome Editor (@somaticediting) + Cell Bioengineer (@CMaT_ERC)
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Articles

Monitoring biological effects of somatic cell genome editing - Nature Reviews Genetics

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By Benjamin Freedman, Charles A Gersbach, John Kelly, John A. Ronald, Krishanu Saha, Divya Sinha, Alice F. Tarantal, Shengdar Tsai, SCGE Dissemination
| Nature Verified
Abstract CRISPR-based genome editing therapeutics are entering the clinic, offering transformative potential but also presenting potential risks. Preclinical-to-clinical toolkits are needed to assess the safety and efficacy of these new therapies and accelerate progress.
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Label-free metabolic imaging monitors the fitness of chimeric antigen receptor T cells - Nature Biomedical Engineering

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By Matthew H. Forsberg, Kayla Sylvester, Jorgo Lika, Madison Bugel, Jing Fan, Christian M. Capitini, Krishanu Saha, Jolanta Vidugiriene
| Nature Verified
Abstract Chimeric antigen receptor (CAR) T cell therapy for solid tumours is challenging because of the immunosuppressive tumour microenvironment and a complex manufacturing process. Cellular manufacturing protocols directly impact CAR T cell yield, phenotype and metabolism, which correlates with in vivo potency and persistence. Although metabolic fitness is a critical quality attribute, how T cell metabolic requirements vary throughout the manufacturing process remains unexplored.
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Base editing as a therapeutic strategy for somatic repeat expansion diseases - Nature Genetics

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By Krishanu Saha
| Nature Verified
CRISPR–Cas base editing of trinucleotide repeats shows promise in reducing somatic repeat expansions in Huntington’s disease and Friedreich’s ataxia, offering a potential new therapeutic strategy.
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See all 17 licensed articles (19 Total)
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