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Krishna Mohan Parsi

As seen in: Cell Press, Cell & Gene Therapy Insights
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Articles by Krishna Mohan Parsi

Recombinant AAV Production Platforms: Comparative insights for gene therapy manufacturing

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By Robert M. Kotin, Krishna Mohan Parsi, Sylvain Cecchini
| Cell & Gene Therapy Insights Verified
Cell and Gene Therapy Insights 2026; 12(9), 889–910 10.18609/cgti.2026.112 Recombinant adeno-associated virus (rAAV) has emerged as a leading platform for gene therapy, leveraging both naturally occurring and engineered capsids to deliver therapeutic transgenes. As clinical and research demand for rAAV has grown, vector quality and manufacturing consistency have become critical considerations.
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Nuclear AGO1 Regulates Gene Expression by Affecting Chromatin Architecture in Human Cells

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By Muhammad Shuaib, Krishna Mohan Parsi, IRCSS Fondazione
| Cell Press Verified
Highlights • AGO1 enrichment on chromatin and transcriptional enhancers is mediated by eRNAs • AGO1 depletion alters global transcriptional output including eRNA transcripts • Enhancer-associated AGO1 contributes to the maintenance of 3D chromatin organization Summary The impact of mammalian RNA interference components, particularly, Argonaute proteins, on chromatin organization is unexplored. Recent reports indicate that AGO1 association with chromatin appears to influence gene expression.
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