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Krister J. Barkovich on Muck Rack

Krister J. Barkovich

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Articles

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

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By Jack Stevenson, Keelan Z. Guiley, Kevin Lou, Krister J. Barkovich
| Science Magazine Verified
Revised view of anticancer drug mechanism A crystal structure of the active form of cyclin-dependent kinase 4 (CDK4) provides insight into regulation of the cell cycle and the mechanism of action of a drug used for breast cancer therapy. The protein p27 has been thought to act as a CDK inhibitor. Guiley et al. performed a structural analysis of active complexes of CDK4 with cyclin D1 (CycD1) and p27 (see the Perspective by Sherr).
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