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Kristin A. Knouse on Muck Rack

Kristin A. Knouse

As seen in: Cell Press
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Articles by Kristin A. Knouse

Genome-scale CRISPR screening in a single mouse liver

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By Heather R. Keys, Kristin A. Knouse
| Cell Press Verified
Highlights • Stable, high-coverage delivery of a genome-scale sgRNA library to the mouse liver • Screen for hepatocyte fitness uncovers significant hits in single mice • Screen reveals genes uniquely required for hepatocyte fitness in a living organism • Approach is accessible and adaptable to diverse phenotypes and CRISPR applications Summary A complete understanding of the genetic determinants underlying mammalian physiology and disease is limited by the capacity for high-throughput genetic...
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Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture

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By Kristin A. Knouse, Kristina Lopez, Marc Bachofner, Angelika Amon
| Cell Press Verified
Highlights • Primary epithelial cells missegregate chromosomes when cultured as monolayers • Organoid culture rescues mitotic defects in an integrin-dependent manner • Tissue architecture promotes correction of merotelic kinetochore attachments • Disruption of tissue architecture could underlie chromosome instability in cancer Summary Much of our understanding of chromosome segregation is based on cell culture systems.
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