Kristin Lebherz on Muck Rack

Kristin Lebherz

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Articles

Modeling length changes in de novo ORFs during neutral evolution

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By Ravi Iyengar, Marie Lebherz, Kristin Lebherz
| Oxford Academic Verified
For protein coding genes to emerge de novo from a non-genic DNA, the DNA sequence must gain an open reading frame (ORF) and the ability to be transcribed. The newborn de novo gene can further evolve to accumulate changes in its sequence. Consequently, it can also elongate or shrink with time. Existing literature shows that older de novo genes have longer ORF, but it is not clear if they elongated with time or remained of the same length since their inception.
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