Kristl Vonck

Abstract While the perihematomal region of a spontaneous intracerebral hemorrhage (ICH) provides a potential therapeutic target, the pathophysiological processes in that region remain unclear. To evaluate the nature, extent and localization of perihematomal changes, we investigated glucose uptake, water diffusion, and cell counts in the acute phase of collagenase-induced ICH. Sprague-Dawley rats were intrastriatally injected with collagenase or saline (control group).

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1 INTRODUCTION Patient-reported outcomes (PRO) are any report of the status of a patient's health condition that comes directly from the patient, without interpretation of the patient's response by anyone else (Food & Drug Administration, U.S. Department of Health & Human Services: Guidance for Industry, 2009). The use of PRO measures in clinical practice is gaining increasing attention.